CPAC: Why Marco Rubio could be the real winner

Marco Rubio came in a close second to Rand Paul in CPAC's presidential straw poll. But Florida's junior senator has a lot going for him as he?has morphed into a mainstream Republican favorite.

By Linda Feldmann,?Staff writer / March 17, 2013

Senator Marco Rubio of Florida speaks at the Conservative Political Action Conference (CPAC) at National Harbor, Maryland March 14. Rubio?s speech got the packed ballroom to its feet with an approach that was more inspirational than hard-edged.

Kevin Lamarque/REUTERS

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Marco Rubio, the junior senator from Florida, came in second Saturday to Kentucky Sen. Rand Paul in the presidential straw poll at the big annual Conservative Political Action Conference, or CPAC.

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But just barely. Senator Rubio got 23 percent to Senator Paul?s 25 ? the only two people to score in double digits of the 23 potential candidates on the ballot (plus 44 write-ins).

There are two big reasons to discount the poll: It?s unscientific and the 2016 presidential election is far away.

Some attendees didn?t bother to vote, they said, because they?re more focused on the 2014 midterms. And more than half (52 percent) of the 2,390 people who did vote were between the ages of 18 and 25 ? hardly typical of the Republican electorate, though reflective of CPAC?s success in attracting young people. Many of today?s college Republicans lean libertarian like Paul.

Still, Rubio can take heart from his performance in the first cattle call of the 2016 cycle. Though elected to the Senate in 2010 as a tea party darling (like Paul), he has morphed into a mainstream GOP favorite. Rubio?s CPAC speech wasn?t as pungent as Paul?s ? ?The GOP of old has grown stale and moss-covered,? the Kentuckyian said ? but he still got the packed ballroom to its feet Thursday with an approach that was more inspirational than hard-edged.

?We don't need a new idea,? Rubio said. ?There is an idea. The idea is called America, and it still works.?

Rubio also tossed in some red meat to social conservatives, defending traditional marriage, opposition to abortion, and skepticism on climate change. But he didn?t dwell on those topics, and on gay marriage, he occupied a middle ground, allowing that states have the right to define marriage how they wish.??

Rubio?s speech was mostly focused on the economy, and he sounded almost Obama-esque in his discussion of the middle class and education. He spoke of a family he knows that wants to reach the middle class, but with parents who lack the training for jobs that would get them there.

?They're not freeloaders. They're not liberals,? Rubio said, winning some laughs. ?They're just everyday people that want what everybody else wants?.They want a better life for themselves and an even better life for their children.?

Except for the slap at liberals, that could have been President Obama speaking. Rubio also played it safe on immigration, making no mention of the issue, his new support for a path to citizenship for illegal immigrants, or his role in the Senate trying to forge a bipartisan consensus.

Paul?s posture was more that of an outsider, attacking Obama and the Washington establishment (of both parties), highlighting his recent 13-hour filibuster over drones, and issuing populist appeals to the young and libertarian-minded.

?Ask the Facebook generation whether we should put a kid in jail for the nonviolent crime of drug use, and you'll hear a resounding no,? Paul said. ?Ask the Facebook generation if they want to bail out too-big-to-fail banks with their tax dollars, and you'll hear a ?Hell no.??

He also tried to outdo House Budget Chairman Paul Ryan of Wisconsin, calling for a budget that reaches balance in five years. (Congressman Ryan?s budget gets there in 10). And he called for elimination of the Department of Education, echoing President Reagan from 30 years ago.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/p09dJbOOIJo/CPAC-Why-Marco-Rubio-could-be-the-real-winner

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Kris Huffman Named D3hoops.com Coach of the Year; Alex Gasaway Earns All-America Honors

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Famous 'HeLa' Human Cell Line Gets Its DNA Sequenced

The genome of the cell line, which originated from a deadly cervical tumor taken from a patient named Henrietta Lacks, is riddled with errors, raising questions about its continued use in research

By Ewen Callaway and Nature magazine

HeLa cells have contributed to work in thousands of research papers but sequencing shows their genome to be full of errors. Image: Flickr/GE Healthcare

The research world?s most famous human cell has had its genome decoded, and it?s a mess. German researchers this week report the genome sequence of the HeLa cell line, which originates from a deadly cervical tumor taken from a patient named Henrietta Lacks.

Established after Lacks died in 1951, HeLa cells were the first human cells to grow well in the laboratory. The cells have contributed to more than 60,000 research papers, the development of a polio vaccine in the 1950s and, most recently, an international effort to characterize the genome, known as ENCODE.

Previous work showed that HeLa cells, like many tumors, have bizarre, error-filled genomes, with one or more extra copies of many chromosomes. To get a closer look at these alterations, a team led by Lars Steinmetz, a geneticist at the European Molecular Biology Laboratory in Heidelberg, Germany, sequenced the popular 'Kyoto' version of the cell line and compared the sequence with that of a reference human genome. The team's results are published in G3.

Steinmetz?s team confirmed that HeLa cells contain one extra version of most chromosomes, with up to five copies of some. Many genes were duplicated even more extensively, with four, five or six copies sometimes present, instead of the usual two.? Furthermore, large segments of chromosome 11 and several other chromosomes were reshuffled like a deck of cards, drastically altering the arrangement of the genes.

Without the genome sequence of Lacks? healthy cells or that of her original tumor, it is difficult to trace the origin of these alterations. Steinmetz points out that other cervical tumors have massive rearrangements on chromosome 11, so the changes in the HeLa cell may have contributed to Lacks? tumor.

Potential uses
Having been replicating in labs around the world for six decades, HeLa cells have also accrued errors not present in the original tumor DNA. Moreover, not all HeLa cells are identical, and Steinmetz says that it would be interesting to chart the cell?s evolution.

Whatever their origin, the genetic changes raise questions over the widespread use of HeLa cells as models for human cell biology, Steinmetz says. For instance, his team found that around 2000 genes are expressed at levels higher than those of normal human tissues because of the duplications. Alternative cell lines, such as induced pluripotent stem cells generated from patient skin cells, offer a more accurate window on human biology, he says.

Mathew Garnett, a cancer biologist at the Wellcome Trust Sanger Institute near Cambridge, UK, says that HeLa cells could prove useful for studying aspects of the biology of cervical tumors, such as their response to cancer drugs. In recent years, the genomes of many cervical tumors have been sequenced, and so it should be possible to see how these compare with the HeLa genome.

Steinmetz also points out that thousands of research papers based on HeLa cells, along with HeLa resources such as genetically manipulated lines and now a genome, means that labs will continue to stock the cells, even if they are not a perfect model of human biology. ?These are not going to go out of fashion over the next 10 years,? he says. "I?m not sure where we?re going to be 20 years from now."

This article is reproduced with permission from the magazine Nature. The article was first published on March 15, 2013.

Source: http://rss.sciam.com/click.phdo?i=6559afa7cdf4bbf1541fc057d184e224

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Federal judge rules surveillance provisions unconstitutional

By Bernard Vaughan

NEW YORK (Reuters) - A federal judge has ruled unconstitutional national security provisions that permit federal investigators to access customer information from some companies without court approval.

The provisions "suffer from significant constitutional infirmities," and violate the First Amendment and separation of powers, Judge Susan Illston of the District Court for the Northern District of California wrote in an order on Thursday.

The judge's decision stems from a "National Security Letter" that the Federal Bureau of Investigation issued to an unnamed telecommunications company, according to the Electronic Frontier Foundation.

The National Security Letter provision of the Patriot Act expanded the FBI's authority to demand personal customer records from Internet service providers, financial institutions and credit companies without prior court approval, according to the American Civil Liberties Union.

The letter to the telecommunications company sought "subscriber information" from the company, and warned that the letter's disclosure could result "in a danger to the United States," among other ramifications, according to the decision.

In the lawsuit, the company challenged the constitutionality of the laws, while the government opposed it and filed its own lawsuit, according to the decision.

"The government has a strong argument that allowing the government to prohibit recipients of NSL's from disclosing the specific information sought in NSL's to either the targets or the public is generally necessary to serve national security in ongoing investigations," Illston wrote. "However, the government has not shown that it is generally necessary to prohibit recipients from disclosing the mere fact of their receipt of NSLs."

(Reporting By Bernard Vaughan)

Source: http://news.yahoo.com/federal-judge-rules-surveillance-provisions-unconstitutional-001457869--finance.html

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White House launches 'Being Biden' audio series

Ever wonder what goes through Vice President Joe Biden's head? The White House has just launched an audio series called "Being Biden," where the vice president will share his story of a photograph in which he appears.

The first picture featured in the series is of Biden's serving rolls at a wild game dinner in Delaware earlier this month. The vice president is shaking hands with a man wearing a hunting-style shirt featuring deer in the woods as Biden carries a tong in his other hand.

"Hey folks, I want to tell you about this picture you're looking at," Biden said about the picture. "These are a couple of guys in their hunting shirts that I'm serving a meal to, along with the folks you see in the back gourd and the occasion is once a year the Whitehall Neck Sportsman Club holds a dinner.

"I've been attending it for over 30 years. It's called a wild game dinner and they go out and they hunt for wild game that they then cook up and serve at the Leipsic fire hall, as you see in the background and all the money goes to charity and then there's an auction and they auction off guns and bows and all that money as well goes to originally went to [defray] the costs and expenses of a buddy of theirs who was injured in a hunting accident years ago and now it goes to help people in need."

Biden then detailed how important the right to bear arms responsibly is to himself and hunters.

"They believe there is a Second Amendment right to own a weapon. So do I, but they also believe that it's for self protection and legitimate uses like hunting and these guys have the ethic, an ethic that I find most sportsmen have, one that demands responsibility in terms of their case how you deal with, treat, and store your weapons, and there's an ethic that they have that says we're going to help those in our community who are in need," Biden said. "I know these guys, and I know an awful lot of them. I've been doing it for over 30 years. They're my friends, but the point is they are absolutely, totally responsible."

The vice president noted that today marks three months since the massacre at Sandy Hook Elementary in Connecticut and urged Congress to pass gun legislation to help prevent such a tragedy in the future.

"This is the third-month anniversary of those twenty beautiful little babies who were massacred up in Connecticut in Sandy Hook and those six brave teachers and administrators that tried to protect them. And the country cries for responsible action, to do everything we can to see to it that these kinds of events don't happen again," he said.

"I'm pleased to say the Judiciary Committee, that's the committee in the United States Senate has passed out the major elements of what we've proposed. They've passed out a gun-trafficking piece of legislation, a universal background check piece, a school safety piece, and I think they're going to do more," Biden said.

"I think it's time the United States Congress act responsibly now and seriously debate the pieces of legislation we've talked about so that we can get to a position where we actually make our communities safer for our children, make our schools safer, and make society safer."

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Source: http://news.yahoo.com/white-house-launches-being-biden-191605591.html

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Melbourne IT sells Digital Brand Services division ... - Online Domain

Melbourne IT (ASX: MLB) today announced it had entered into definitive agreements with respect to the sale of its Digital Brand Services (DBS) division to US-based Corporation Services Company (CSC) for a cash consideration of A$152.5 ($157.2 USD) million. The completion of the transaction occurred simultaneously with execution of these agreements.

Key Points:

• A$152.5 million cash received by Melbourne IT for Digital Brand Services (DBS) division
• Board considering capital management options including special dividends, capital returns, share buybacks and business investment options for use of DBS sale proceeds
• Melbourne IT strongly positioned for future growth with systems transformation project in its final year
• Management and Board to deliver updated Melbourne IT strategic business plan to shareholders by AGM in May

DBS provides online brand protection and consultancy services to large global organisations seeking to maximise the value of their online assets. The division was created in 2008 when Melbourne IT combined its Corporate Brand Services division with the Verisign DBMS business which the company had acquired for US$50 million.

The agreed sale price of A$152.5 million for DBS illustrates a significant growth in value of the business over the past four years, and represents a valuation of 16x 2012 segment EBIT (pre-corporate allocations) of $9.5 million and is equivalent to 95% of Melbourne IT?s market capitalisation pre-DBS sale (as of 11 March 2013). The sale achieves the Melbourne IT Board?s stated objective of its strategic review to unlock shareholder value by realising the intrinsic value of its businesses.

Melbourne IT Chairman, Simon Jones, said: ?The Board firmly believes this transaction is in the interests of shareholders.?

Ten per cent of the A$152.5 million purchase price will be held in escrow for 15 months. Net proceeds from the transaction will depend on Melbourne IT?s capital gains tax liability, transaction and other associated costs, and other sale related adjustments, however are expected to be in the order of A$135-140 million. After retiring outstanding debt of US$35 million, Melbourne IT will consider a range of capital management options as a result of the sale.

?The sale of DBS is a substantial result for shareholders. The transaction has crystallised a value for the business almost equivalent to Melbourne IT?s current market capitalisation, and represents a strong multiple of earnings relative to other recent transactions for this type of business. While this was not a business that we had specifically earmarked for sale, given the value creation provided by the transaction, this was an opportunity which could not be ignored,? Melbourne IT CEO and Managing Director, Theo Hnarakis, said.

?Management and the Board are now concentrating on updating the strategic plan for the business following the divestiture so we can provide clarity to shareholders before the AGM in May. We are confident that Melbourne IT?s remaining business divisions will benefit significantly from the arrival of new gTLDs, the completion of the Transformation program, and management?s clearer focus on executing our plans,? he said.

Corporation Service Company (CSC) Vice President, Jim Stoltzfus, said of the sale: ?We were attracted to the global scale and capabilities of DBS to combine with CSC?s leadership position in providing corporate domain and online services to create the best partner for companies worldwide to turn to for helping them manage, promote and protect their brands in the digital marketplace.?

The proceeds of the DBS sale will be realised in Melbourne IT?s 2013 financial year which began January 1, 2013. In the interest of shareholders, Melbourne IT has decided to suspend the Dividend Reinvestment Plan while the strategic review completes.

Melbourne IT is being advised on the transaction by King & Wood Mallesons and Lazard.
ENDS.

About Melbourne IT
Melbourne IT (ASX: MLB) helps organizations of all sizes to successfully conduct business online. Our complete portfolio of Internet-based technology services drives business effectiveness and profitability for more than 400,000 customers around the world.

The breadth of Melbourne IT?s offering extends from helping small businesses build an online presence through to managing the complex technology environments of large enterprises and governments ? including Internet domain name services, web hosting, online brand protection and promotion, managed IT services and more.

Melbourne IT?s culture of integrity, innovation, collaboration and customer centricity has been built by more than 650 employees spread across 18 offices in 10 countries. For more information, visit www.melbourneit.info.

About Corporation Service Company
Founded in 1899, Corporation Service Company (CSC) provides business, legal, and financial services to many of the world?s largest companies, law firms, and financial institutions.

An ICANN-accredited domain name registrar since 1999, CSC is the trusted partner of more than half the 100 Best Global Brands (Interbrand?) and the customer approval leader for domain name and online services (World Trademark Review, 2010). CSC offers an end-to-end solution for every corporate brand protection need, from strategic domain registration and online monitoring to digital certificates and trademark screening.

CSC has more than 1,600 employees located throughout North America and Europe. Visit www.cscglobal.com to learn more.

About the Author:

Konstantinos Zournas lives in Athens, Greece. He studied Computer Engineering and Computer Science in the UK. He has been a domainer, among other things, for the past 10 years. He does consulting, website development and programming. He is mainly writing about domain names but other things may come up. You can find him at Google+

Konstantinos Zournas ? who has written 454 posts on Online Domain.

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Source: http://onlinedomain.com/2013/03/12/news/melbourne-it-sells-digital-brand-services-division-for-157-2-million-to-corporation-service-company-csc/

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Regardless of possible weight gain, quitting smoking associated with reduced risk of cardiovascular disease

Mar. 12, 2013 ? Among adults without diabetes, quitting smoking, compared with continuing smoking, was associated with a lower risk of cardiovascular disease despite subsequent weight gain, according to a study appearing in the March 13 issue of JAMA.

"Cigarette smoking is the leading cause of preventable mortality in the United States and a major risk factor for cardiovascular disease (CVD). Smoking cessation substantially reduces the risks of CVD; however, quitting smoking is associated with a small number of adverse health consequences, weight gain being one of smokers' major concerns," according to background information in the article. The average postcessation weight gain varies between 6.6 lbs. and 13.2 lbs. in North America, happens within 6 months after smoking cessation, and persists over time. Obesity is also a risk factor for CVD. Weight gain following smoking cessation therefore might lessen the benefits of quitting smoking on CVD outcomes. In addition, among people with type 2 diabetes, weight gain following smoking cessation has potential to be of greater concern because it is a risk factor for poor diabetes control and increased risk of illness and death. "The effect on CVD of potential weight gain following smoking cessation is not well understood," the authors write.

Carole Clair, M.D., M.Sc., of the University of Lausanne, Switzerland, and colleagues conducted a study to assess the association between 4-year weight gain following smoking cessation and CVD event rate among adults with and without diabetes. The study included data from the Framingham Offspring Study collected from 1984 through 2011. At each 4-year examination, self-reported smoking status was assessed and categorized as smoker, recent quitter (? 4 years), long-term quitter (>4 years), and nonsmoker. Models were used to estimate the association between quitting smoking and 6-year CVD events and to test whether 4-year change in weight following smoking cessation modified the association between smoking cessation and CVD events. The primary outcome measure was the incidence over 6 years of total CVD events, comprising coronary heart disease, cerebrovascular events, peripheral artery disease, and congestive heart failure.

Weight gain occurred over 4 years in participants without and with diabetes. Among participants without diabetes, recent quitters gained significantly more weight (median [midpoint], 5.9 lbs.) than long-term quitters (1.9 lbs.), smokers (1.9 lbs.), and nonsmokers (3 lbs.). Among patients with diabetes, recent quitters also gained significantly more weight (7.9 lbs.) than smokers (1.9 lbs.), long-term quitters (0.0 lbs., and nonsmokers (1.1 lbs.).

After an average follow-up of 25 years, 631 CVD events occurred among 3,251 participants. The researchers found that among participants without diabetes, the age- and sex-adjusted CVD incidence rates were lower for nonsmokers, recent quitters, and long-term quitters, compared with smokers.

After adjustment for CVD risk factors, compared with smokers, recent quitters had a 53 percent lower risk for CVD and long-term quitters had a 54 percent lower risk for CVD; these associations had only a minimal change after further adjustment for weight change. "Among participants with diabetes, there were similar point estimates that did not reach statistical significance," the authors write.

The researchers observed similar benefits associated with smoking cessation for total CVD and for fatal and non-fatal coronary heart disease, with the cessation benefits not offset by weight gain.

"In conclusion, among adults without diabetes, quitting smoking was associated with a lower risk of CVD compared with continuing smoking. There were qualitatively similar lower risks among participants with diabetes that did not reach statistical significance, possibly because of limited study power. Weight gain that occurred following smoking cessation was not associated with a reduction in the benefits of quitting smoking on CVD risk among adults without diabetes. This supports a net cardiovascular benefit of smoking cessation, despite subsequent weight gain," the authors write.

Editorial: Should Clinicians Encourage Smoking Cessation for Every Patient Who Smokes?

In an accompanying editorial, Michael C. Fiore, M.D., M.P.H., M.B.A., and Timothy B. Baker, Ph.D., of the University of Wisconsin School of Medicine and Public Health, Madison, suggest ways in which the findings of this study can be used by physicians.

"First, data from the study by Clair et al can be used to reassure patients concerned about the health effects of cessation-related weight gain. About 50 percent of female smokers and about 25 percent of male smokers are 'weight concerned,' which may discourage quit attempts and quitting success. Although such reassurance may not assuage concerns about the effects of weight gain on appearance, it may nevertheless be helpful. Furthermore, even though no treatments have been shown to reliably prevent cessation-related weight gain, exercise regimens may be beneficial, and use of nicotine replacement medications can suppress weight gain during their use. Second, physicians should use this information to reinforce their commitment to provide or arrange evidence based treatment for all of their patients who smoke."

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Story Source:

The above story is reprinted from materials provided by The JAMA Network Journals.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal References:

1. Clair C, Rigotti NA, Porneala B, et al. Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among Adults With and Without Diabetes. JAMA, 2013; 309 (10): 1014-1021 DOI: 10.1001/jama.2013.1644
2. Fiore MC, Baker TB. Should Clinicians Encourage Smoking Cessation for Every Patient Who Smokes? JAMA, 2013; 309 (10): 1032-1033 DOI: 10.1001/jama.2013.1793

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/B6kQVswggog/130312161148.htm

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