মঙ্গলবার, ৬ নভেম্বর, ২০১২

Lawyer: Vatican expert had little motive to steal

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বুধবার, ৩১ অক্টোবর, ২০১২

Oxidative stress and altered gene expression occurs in a metabolic liver disease model

ScienceDaily (Oct. 29, 2012) ? A team of researchers under the direction of Dr. Jeffrey Teckman in the Department of Pediatrics at St. Louis University, have demonstrated that oxidative stress occurs in a genetic model of alpha-1-antitrypsin deficiency. This is the most common genetic liver disorder in children and can lead to cirrhosis and hepatocellular carcinoma in adults. Some cases may require liver transplantation.

The report, published in the October 2012 issue of Experimental Biology and Medicine, suggests that treatment with antioxidants might be of therapeutic benefit for some individuals.

"We have evidence of oxidative stress in livers from an animal model that expresses the classical Z variant form of alpha-1-antitrypsin. The animal model recapitulates the human liver disease, in which the livers accumulate polymers of alpha-1-antitrypsin mutant Z protein, developing fibrosis and hepatocellular carcinoma with age," says Dr. Marcus. Potentially, non-invasive treatment involving long-term regulation of antioxidant levels could ameliorate the oxidative stress and retard the advancement of disease.

"This is an exciting new report which may help us understand the extreme variability between different patients with this same, single gene, metabolic liver disease. These findings may inform the pathophysiology of other liver diseases as well," says Dr. Teckman. In clinical studies, liver disease from alpha-1-antitrypsin mutant Z protein has shown considerable variability in severity and progression, suggesting that as yet undescribed genetic modifiers may influence disease development. Based on this study, certain antioxidant enzymes involved in oxidative stress defense could be useful targets for further examination. Using microarray technology, the investigators have identified a number of potential alterations in gene expression pathways that could modify the development of liver pathologies. This information could be useful in defining genetic variants that may influence individual susceptibility and in facilitating the design of appropriate treatments.

Steven R. Goodman, PhD, Editor-in-Chief of Experimental Biology and Medicine said, "Teckman and colleagues have demonstrated that oxidative stress occurs in an animal model of Alpha-1-antitrypsin deficiency. This suggests that antioxidant treatment may be beneficial in this most common genetic liver disorder in children."

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The above story is reprinted from materials provided by Society for Experimental Biology and Medicine, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. N. Y. Marcus, K. Blomenkamp, M. Ahmad, J. H. Teckman. Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency. Experimental Biology and Medicine, 2012; DOI: 10.1258/ebm.2012.012106

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/aG8p31SCRz8/121030062609.htm

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সোমবার, ২৯ অক্টোবর, ২০১২

Affordable Website Designers Boost Small Business Website ...

Affordable website designers are professional teams or firms which can pull together a positive website design package for small businesses for the right price. Small businesses often rush to establish an online presence in the hopes of garnering lots of traffic and online sales. Many will contract with web designers without investigating the designer's track record or web portfolio. The lure is a really cheap price with the promise of a top spot in the search engines within days. What they get for their investment is usually a template or "cookie-cutter" website that fails to differentiate the business from its competitors. Further, there is usually no immediate increase in traffic or sales as "promised."

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Alternatively, a small business may opt to do their website on their own or in-house. While not allocating any serious budget estimates or competitive research, a website is inadvertently designed to personal expertise and may not result in a professionally appealing design. Hence, no traffic or online sales result. Using professional, yet affordable, website designers will ensure a small business can get a coherent, online presence established to grow traffic and increase sales in a progressive manner. Professional web designers will analyze a small business goals and competition early in the design process. This analysis produces a focused target market for the business and develops the initial keywords and phrases necessary to leverage content and traffic.

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An online business presence should be easily tied to the physical aspects of the small business. The business logo, if it exists, is the primary thematic element tying the on and offline business together. Affordable website designers ensure the business logo is incorporated into the website theme. If no logo exists, graphic artists can produce several options for selection. Once complete the logo is trademarked and incorporated into all aspects of the business. With the "branding" completed in the website design, a unique identity emerges for a professional online presence.

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Content and linking strategies are the main tools of search engine optimisation (SEO). SEO is the process of making the website easily indexed and consumed by search engines. Natural, relevant and fresh content and links indicate the website has value and is used by the Internet consumer. Professional designers never use automated or randomly generated content to quickly over populate a website. A strategy for slow build-up of relevant, human readable content ensures quality traffic and higher placement with the search engines as an authoritative website. Investing in affordable website designers will pay a huge return on investment for a small business in repeat traffic and sales.

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James Allen is author of this article. To know more about affordable website designers, website design Brisbane and ecommerce website developer, please visit http://www.totalwebdesign.com.au

Source: http://www.webarticlecollection.com/affordable-website-designers-boost-small-business-website-investment-returns/?utm_source=rss&utm_medium=rss&utm_campaign=affordable-website-designers-boost-small-business-website-investment-returns

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শনিবার, ২০ অক্টোবর, ২০১২

PHOTOS: Kate Hudson Takes Her Sons to Paris!

Kate Hudson is spotted at the Paris aiport with her two boys! Plus, see more photos of celebs spending time with their loved ones!

Source: http://www.ivillage.com/star-snapshots-celebrity-kids-and-family-photos-2012/1-b-462723?dst=iv%3AiVillage%3Astar-snapshots-celebrity-kids-and-family-photos-2012-462723

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Attorneys To Release Confidential Boy Scouts Files On Alleged ...

(CNN) ? More than 20,000 confidential Boy Scout documents will be released Thursday identifying more than 1,000 leaders and volunteers banned from the group after being accused of sexual or inappropriate conduct with boys.

The public release of the Scouts? 1,247 ?ineligible volunteer files? from 1965 to 1985 will not contain the identities of the boy victims and witnesses. The national files are being distributed with the approval of the Oregon Supreme Court by a law firm that won an $18.5 million judgment in 2010 against the Boy Scouts in a case where a Scoutmaster sexually abused a boy.

Wayne Perry, president of Boy Scouts of America, said the group is deeply committed to youth protection, but he acknowledged that in some cases, the organization?s response to allegations of abuse by volunteers ?were plainly insufficient, inappropriate or wrong.?

?Where those involved in Scouting failed to protect, or worse, inflicted harm on children, we extend our deepest and sincere apologies to victims and their families,? Perry said in a statement issued Wednesday evening. ?While it is difficult to understand or explain individuals? actions from many decades ago, today Scouting is a leader among youth-serving organizations in preventing child abuse.?

The Boy Scouts opposed the release of the internal records and said their confidentiality has encouraged prompt reporting of questionable behavior and privacy for victimized boys and their families.

?While we respect the court, we are still concerned that the release of two decades? worth of confidential files into public view, even with the redactions indicated, may still negatively impact victims? privacy and have a chilling effect on the reporting of abuse,? the organization said.

The Scouts also released a September report from a University of Virginia psychiatry professor, Janet Warren, who concluded that the system ?has functioned well in keeping many unfit adults out of Scouting.?

But the attorneys representing victims in several lawsuits against the Scouts say the group hid evidence from the public and police and that the so-called ?perversion files? offer insight into what they deem a serious problem in the organization.

The secrecy protected more than 1,000 suspected child molesters, said the attorneys, who will publicly release the documents during a news conference in a downtown Portland hotel. The attorneys are also seeking the release of post-1985 files from the Boy Scouts.

The files will show that the expelled Scout leaders and volunteers ? all men ? ?are sociopathic geniuses,? said attorney Kelly Clark of Portland, who has reviewed the 20,000 pages and is among the attorneys releasing the papers Thursday.

?They fool everybody,? he said. ?And then they are able to coerce, convince or threaten these kids to stay silent. And you see that play out over and over again in the files.?

Clark said he represents more than 100 men who as children were in the Boy Scouts, and he estimates that more than 50% of his clients have drug or alcohol problems. At least three of them have committed suicide, he said.

Tim Kosnoff, an attorney in Seattle, said the abuse allegedly inflicted on the men as boys ?has a corrosive effect? in which trust, relationship and sexuality issues develop with adulthood.

One former Boy Scout represented by Kosnoff, Keith Early, joined the group at 12, recruited by an assistant Scoutmaster who was a married firefighter with three children and led Scout meetings in a church in Washington state.

Early, now 18, was sexually abused by the Scout leader while helping build a Boy Scout camp on his 42-acre ranch, he said in an interview with CNN. The assistant Scoutmaster was convicted of abusing Early and another boy and is now serving a prison sentence of 10 years to life.

?I felt like I was all alone,? Early said. ?Just thinking about it makes me angry ? because how could you do that to somebody? How could you bring yourself to do that to somebody who is so innocent and has done nothing wrong??

The number of files started each year ranged from 25 to 75 at a time when about 5 million Scouts and volunteers were active, according to Warren?s report. In most cases, ?police, courts and public were aware of the information in the files,? and 58% ?included information known to the public.?

There were ?a small number of files where an alleged offender was allowed back into Scouting after offending,? often after psychiatric treatment, ?those cases were extraordinarily rare,? wrote Warren, who was an expert witness for the Boy Scouts during the court case.

Tim Hale, a Santa Barbara, California, attorney who?s representing allegedly abused Scouts who are now adults, said the released documents could provide information about possible pedophiles.

?We?re talking about hundreds, if not thousands, of unidentified men who should be registered sex offenders who are roaming free in society, free to volunteer with other youth organizations, to work at schools and that sort of thing,? Hale said.

The Boy Scouts disputes that characterization of their files.

In a September 20 statement released by the Boy Scouts, Warren rebutted the characterization that the documents were ?secret files of hidden abuse? by pedophiles.

?The files show a significant amount of public knowledge of the offenders and their unlawful acts. For example, over 60% of the files being made available to the public include some kind of public information. These public domain sources included newspaper articles, police reports, criminal justice records, and records of civil litigation. The majority of men in the files were arrested at some point in their lives for a sex crime,? Warren wrote.

The files are also ?very limited in their ability to answer important research questions about sexual abuse,? she said.

?While some have attempted to categorize these files as a ?treasure trove? of information about pedophiles and their actions, that simply is not the case,? Warren said. ?These files tell us precisely what researchers already knew, and have known for many years: some small number of men will use a position of trust and access to young people to pursue illegal sexual gratification. This is a sad reality that has been with us throughout human history.?

The Boy Scouts say they have improved their youth protection policies the past decade and have initiated such practices as third-party, computerized background checks on all new adult volunteers. Also, at least two adults are present at all scouting activities, the group said.

The Scouts, founded by congressional charter in 1910, instituted character reference checks for Scoutmasters in 1911 and, by the 1920s, began using an ineligible volunteers list deemed not having ?the moral, emotional or character values for membership,? the group said.

In June, the Oregon Supreme Court upheld a lower-court decision to release the documents as requested by media outlets.

?The court had discretion to order, on good cause shown, the release of those documents subject to the redaction of names set out in the exhibits to protect victims of child sexual abuse and reporters of child sexual abuse from embarrassment, retaliation or other harm,? the state Supreme Court said in its order. ?The court in this case properly exercised that authority.?

The media companies seeking the release of the files were the Associated Press, The Oregonian newspaper in Portland, Oregon Public Broadcasting, KGW (a CNN affiliate), The New York Times and Courthouse News Service.

Those media outlets intervened in a 2010 lawsuit in Oregon that resulted in the largest judgment against the Scouts in a molestation case.

That year, an Oregon jury found the Boy Scouts liable for the sexual abuse of a 12-year-old boy more than 25 years earlier, returning a verdict of $18.5 million in punitive damages.

The plaintiff, Kerry Lewis, then 38, allowed his name to be used publicly during the trial, according to his attorneys. He was among six men suing the Boy Scouts over allegations of sexual abuse.

Lewis? attorney, Clark, produced documents during the six-week trial that he said were part of an archive of previously secret Boy Scout files chronicling decades of abuse of boys.

Clark said that when his clients were boys during the 1980s, the Boy Scouts knew that at least one of them had been abused by a former assistant Scoutmaster. At the time of the 2010 trial, that former assistant Scoutmaster was a 53-year-old convicted sex offender released from prison in 2005 and paroled until 2013.

Clark also alleged that though the Scout leader was removed, he was allowed to stay on as a volunteer and the abuse continued. In 1983, the assistant Scoutmaster told troop leaders he abused 17 Scouts, according to plaintiff?s attorneys.

In its verdict, the jury held the Boy Scouts of America 60% negligent; the Cascade Pacific Council, which oversees Scouting activities in the region, 15% negligent; and the Church of Jesus Christ of Latter-day Saints 25% negligent.

The church has sponsored a number of Boy Scout troops, including the one to which the plaintiff belonged. A lawyer representing the church said then that the verdict had no impact on the church, because it settled the case out of court more than a year earlier.

? & ? 2012 Cable News Network, Inc., a Time Warner Company. All rights reserved.

Source: http://fox2now.com/2012/10/18/attorneys-to-release-confidential-boy-scouts-files-on-alleged-child-sex-abusers/

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APNewsBreak: Tenn.'s meningitis has likely peaked

(AP) ? Tennessee's chief medical officer says the rate of new infections from a deadly fungal meningitis outbreak appears to be declining in the state where it was first discovered.

Dr. David Reagan said in an interview Thursday that not everyone who received the contaminated medicine that caused the infections will get sick.

He said the most important factor determining who does get sick is how much fungus was contaminating the vial of medication they received, not their age or even how healthy they were. Tennessee's meningitis patients range in age from 23 to 91.

Tennessee has 66 of the 271 patients sickened with meningitis or joint infections. Eight of the 21 who have died were in Tennessee.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-10-19-Meningitis%20Outbreak/id-bf575c1780934abaa0e9f8b1584e1db1

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রবিবার, ১৪ অক্টোবর, ২০১২

Application For Bankruptcy - Business & Financial News, Breaking ...

Shelter, clothes and food are the primary requirements of humans for survival. Nowadays, because of the lifestyles we?re living that primary need can be adjusted to include money. This really is simply because nowadays all primary wants possess a price tag attached to them.

It can not be denied that there are many men and women these days that are filing for medical bankruptcy. What exactly is the meaning of this term? Continue reading to get a far better understanding simply because you need to have a working knowledge just in case it happens to you.

Medical Bankruptcy is truly not a term that is employed on a regular basis. In the event you want to file for bankruptcy, you demand Chapter 7 bankruptcy. With this sort of bankruptcy, you are needed to itemize all of your debts, each non-medical and medical-related debts. Also, you?ll need to list all your creditors.

That are the people that happen to be most likely to experience economic difficulties? According to bankruptcy statistics, the elderly and single mothers are the ones who typically file for bankruptcy. It is a known reality that as you get older your wellness deteriorates, this implies you get sick more frequently. As for single mothers they?re responsible for all of the medical bills of their youngsters and themselves. Each these scenarios give the single moms? and the elderly mountainous medical bills which offers them no other option but to file for bankruptcy after a period of time.

Yet another worthy question citizens ask is, ?how can I file for bankruptcy?? There is a straightforward answer. You only require to prepare all the prerequisites and file for it. However it ought to be noted that if you filed for the bankruptcy when, you are not in a position to file again for six years. This only indicates that you are not protected from unexpected and undesirable debts for the set periods.

Aldo Clark is a writer that writes about matters that relate to credit card bankruptcy, and other interesting topics including bankrupt credit.

Related posts:

  1. Pointers On The Best Way To Avoid Bankruptcy
  2. Repairing Your Bad Credit By Utilizing Bankruptcy
  3. Be Familiar With Consumer Bankruptcy And Also The Process Involved
  4. Are You Considering Voluntary Bankruptcy
  5. Is It Really Possible To Keep A Visa Card While Filing For Bankruptcy?

Source: http://finance.trustdote.com/application-for-bankruptcy/

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