LONDON (AP) -Gervinho scored one goal and set up two others as Arsenal beat Reading 4-1 on Saturday, boosting its chances of Champions League football next season and ruining Nigel Adkins' return to managerial life in the Premier League.
The Ivory Coast forward set Arsenal on its way with the opener in the 11th minute and then provided assists for Santi Cazorla and Olivier Giroud to net in the second half.
Hal Robson-Kanu pulled a goal back for Reading, but Mikel Arteta ended the struggling visitors' hopes of an unlikely comeback by slotting home a penalty 13 minutes from time.
The victory lifts Arsenal to within two points of fourth-place Chelsea and drops Reading provisionally bottom of the table after Adkins' first game in charge of the club.
"I thought Arsenal were very good, they've passed the ball very well," said Adkins, who was fired by Southampton in January. "Unfortunately, we've made our own downfall on a couple of goals."
The Emirates Stadium wasn't exactly an ideal venue for Adkins to resume his coaching career, with Arsenal full of confidence after back-to-back 2-0 wins against Bayern Munich and Swansea before the international break.
And Gervinho, back in favor at Arsenal following a mid-season slump in form, continued the team's momentum by smashing in from close range after Cazorla drove in a cross. The Ivory Coast forward also scored against Swansea.
"He was always lively and created many dangerous situations," Wenger said of the much-maligned Gervinho.
Cazorla, the instigator of many Arsenal attacks, clipped in a great finish from the edge of the area in the 48th after being picked out by Gervinho, who then led a counter-attack in the 68th and passed for Giroud to drill home low to make it 3-0.
Robson-Kanu stooped to head in a cross from the left a minute later, with Arsenal left back Nacho Monreal having to go off after injuring his knee in the build-up to the goal.
But Arteta ensured there were no late anxieties for the hosts by calmly stroking in a penalty after Alex Oxlade-Chamberlain was fouled.
"We played with good collective spirit, technical quality and always went forward," Wenger said. "We created many chances, that's the most pleasant thing. We defended well, had good discipline and didn't become easy when the game became easy."
Arsenal is four points behind third-place Tottenham with a game in hand.
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Mar 26 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $3,787,600 2. Brandt Snedeker $2,859,920 3. Matt Kuchar $2,154,500 4. Steve Stricker $1,820,000 5. Phil Mickelson $1,650,260 6. Hunter Mahan $1,553,965 7. John Merrick $1,343,514 8. Dustin Johnson $1,330,507 9. Russell Henley $1,313,280 10. Kevin Streelman $1,310,343 11. Keegan Bradley $1,274,593 12. Charles Howell III $1,256,373 13. Michael Thompson $1,254,669 14. Brian Gay $1,171,721 15. Justin Rose $1,155,550 16. Jason Day $1,115,565 17. Chris Kirk $1,097,053 18. ...
The government has promised to help UK businesses "compete" more effectively in the global nuclear energy market.
Ministers have promised ?18m to 35 research projects and ?15m for a "world-class" central resource for firms developing technology.
It is estimated the UK's nuclear build programme could create 30,000 jobs.
All but one of the country's 16 reactors - supplying almost a fifth of the UK's power - are set to close by 2023, with replacements planned.
Business Secretary Vince Cable and Energy Secretary Ed Davey jointly launched the Nuclear Industrial Strategy, promising to help "UK compete in the ?1 trillion global nuclear industry" by tackling skills shortages.
It covers building, waste management, decommissioning, operations and maintenance.
'Successful'
Mr Cable said: "Nuclear power has the potential to play an increasing role in meeting the UK's future energy needs. It is a source of low-carbon energy and can contribute to the UK's energy mix and security of supply longer-term.
"This strategy - like those for offshore wind and oil and gas - will achieve a more effective alignment and integration of energy and industrial policy to enable the UK to deliver competitive energy technologies in future, with significant input from UK-based industry."
He also said: "Part of industrial strategy is about supporting successful sectors. Today's nuclear strategy is one of several sector strategies we will be developing between now and the summer in partnership with industry.
"And this is one of three that focuses on energy industries: the others being offshore wind and oil and gas."
Ministers say ?930bn will be invested globally in building reactors over the next 20 years, with ?250bn being spent on decommissioning disused stations.
The strategy will be overseen by a Nuclear Industry Council, co-chaired by ministers and industry.
In 2011 the government announced that new reactors could be built on land adjacent to old sites at Bradwell, Essex; Hartlepool; Heysham, Lancashire; Hinkley Point, Somerset; Oldbury, Gloucestershire; Sellafield, Cumbria; Sizewell, Suffolk; and Wylfa, Anglesey.
Planning permission was granted last week for the Hinkley Point station, the first such facility to be built in the UK since 1995.
But in February, Centrica, which owns British Gas, withdrew from the UK's nuclear re-building programme because of increasing costs and delays.
There have been questions about the financial viability of new nuclear power plants as a result of the coalition agreement pledge to only allow them "provided they receive no public subsidy".
Instead the government is set to fix the future price of new nuclear electricity, to give investors the certainty of a future income stream.
The global future of nuclear as a power source was also called into question after the disaster which occurred in March 2011 when a Japanese earthquake and tsunami rocked the reactors at Fukushima, leaving radioactivity leaking from the plant.
New England College of Business and Finance (NECB), recently named by the U.S. Department of Education as the most affordable private college in New England and the leading institution of online education designed for working adults seeking career advancement, today announced it is hosting a free webinar for individuals interested in learning more about educational and career opportunities within the high-growth international business field. Dr. Jeff Slattery, Program Chair of the NECB International Business program, will lead the webinar, ?Business Without Borders,? on Friday, April 5 at 1:00 p.m. EST.
During the one-hour webinar, participants will learn about globalization trends in business, the specific skills and education needed to successfully conduct business internationally and the career opportunities available in the growing international business segment.
?In an increasingly connected and globalized world, it?s more important than ever for professionals of all levels to have a comprehensive education and strong business knowledge to compete on a global scale,? said Dr. Slattery. ?The Business Without Borders webinar is yet another way NECB is using social technologies to connect with faculty, current and prospective students, and staff, while also sharing relevant information and resources.?
Dr. Slattery has vast experience in the international business field. He previously served as the War Room facilitator for Conexant Microsystems, Inc., a provider of solutions for imaging, audio, embedded modem, and video surveillance applications with foundries and manufacturing across the globe. He also worked as a Research Associate for the International Trade Center, and continues to write, publish, and speak on topics related to international business and education.
As part of the webinar, Dr. Slattery will discuss NECB?s new Bachelor of Science in International Business program, which is slated to begin in May. Students enrolled in the program will take courses, including International Trade and Global Marketing, which will better position them to shape and navigate the complexities of international business, today and in the future.
Individuals interested in participating can register for the webinar at http://www.necb.edu/ibwebinar/register. For those unable to attend, please visit NECB?s Twitter handle, where the college will share webinar highlights during the event, and follow the hashtag ?#IBedu.?
About New England College of Business and Finance
Founded in 1909, New England College of Business and Finance (NECB) is a leading Boston institution offering quality education and online degrees at the undergraduate and graduate levels. Serving students across the United States, NECB is an online college accredited by the New England Association of Schools and Colleges (NEASC), and is licensed by the Massachusetts Department of Higher Education. For information on NECB, visit www.necb.edu, follow NECB on Twitter or connect with the school on Facebook.
FORT POLK, La. ? They call it the Boar Battle Wagon.
Pfc. Jonathan Bole, a soldier in 2nd Battalion, 30th Infantry Regiment, 4th Brigade Combat Team, 10th Mountain Division, has pimped out a John Deere Gator all-terrain vehicle with some of the latest communications gear from the U.S. Army for potential use on an upcoming deployment to Afghanistan.?I have built a little mobile-command post for the colonel,? he said in an interview.
The brigade, based here at Fort Polk, La., will be the first in the service to deploy with new radios and networking equipment designed to boost mobile connectivity on the battlefield. Soldiers are receiving accelerated training with the technology, which includes smartphone-compatible radios made by General Dynamics Corp., before a planned deployment this spring.
The radios, antennae and laptops came installed on heavy, blast-proof trucks, known as mine-resistant ambush-protected all-terrain vehicles, or M-ATVs, made by Oshkosh. Bole, acting on orders from his commander, Lt. Col. Alan Boyer, assembled the systems on an ATV to see if he could get them working on a smaller vehicle that could fit into a CH-47 Chinook helicopter.
?Something I asked my staff to do, my communications experts, is to create me a mission-command platform that is of medium weight, that I could put onto a CH-47 and fly to an austere, expeditionary environment, that would provide mission-command over my troops and the operations,? Boyer said. ?They took my intent and came up with the Boar Battle Wagon.?
The result is a communications suite that can be powered by a small generator and provide everything from analog radio to satellite communications, as well as the ability to send instant messages, download intelligence feeds and digitally observe troop movements, Boyer said.
The unit is known as the Wild Boars, presumably after the animals that roam stretches of the military post,??located about 130 miles south of Shreveport.
Mar. 25, 2013 ? Researchers studied thousands of ceramic and obsidian artifacts from A.D. 1200-1450 to learn about the growth, collapse and change of social networks in the late pre-Hispanic Southwest.
The advent of social networking sites like Facebook and Twitter have made us all more connected, but long-distance social networks existed long before the Internet.
An article published this week in the Proceedings of the National Academy of Sciences sheds light on the transformation of social networks in the late pre-Hispanic American Southwest and shows that people of that period were able to maintain surprisingly long-distance relationships with nothing more than their feet to connect them.
Led by University of Arizona anthropologist Barbara Mills, the study is based on analysis of more than 800,000 painted ceramic and more than 4,800 obsidian artifacts dating from A.D. 1200-1450, uncovered from more than 700 sites in the western Southwest, in what is now Arizona and western New Mexico.
With funding from the National Science Foundation, Mills, director of the UA School of Anthropology, worked with collaborators at Archeology Southwest in Tucson to compile a database of more than 4.3 million ceramic artifacts and more than 4,800 obsidian artifacts, from which they drew for the study.
They then applied formal social network analysis to see what material culture could teach them about how social networks shifted and evolved during a period that saw large-scale demographic changes, including long-distance migration and coalescence of populations into large villages.
Their findings illustrate dramatic changes in social networks in the Southwest over the 250-year period between A.D. 1200 and 1450. They found, for example, that while a large social network in the southern part of the Southwest grew very large and then collapsed, networks in the northern part of the Southwest became more fragmented but persisted over time.
"Network scientists often talk about how increasingly connected networks become, or the 'small world' effect, but our study shows that this isn't always the case," said Mills, who led the study with co-principal investigator and UA alumnus Jeffery Clark, of Archaeology Southwest.
"Our long-term study shows that there are cycles of growth and collapse in social networks when we look at them over centuries," Mills said. "Highly connected worlds can become highly fragmented."
Another important finding was that early social networks do not appear to have been as restricted as expected by settlements' physical distance from one another. Researchers found that similar types of painted pottery were being created and used in villages as far as 250 kilometers apart, suggesting people were maintaining relationships across relatively large geographic expanses, despite the only mode of transportation being walking.
"They were making, using and discarding very similar kinds of assemblages over these very large spaces, which means that a lot of their daily practices were the same," Mills said. "That doesn't come about by chance; it has to come about by interaction -- the kind of interaction where it's not just a simple exchange but where people are learning how to make and how to use and ultimately discard different kinds of pottery."
"That really shocked us, this idea that you can have such long distance connections. In the pre-Hispanic Southwest they had no real vehicles, they had no beasts of burden, so they had to share information by walking," she said.
The application of formal social network analysis -- which focuses on the relationships among nodes, such as individuals, household or settlements -- is relatively new in the field of archaeology, which has traditionally focused more on specific attributes of those nodes, such as their size or function.
The UA study shows how social network analysis can be applied to a database of material culture to illustrate changes in network structures over time.
"We already knew about demographic changes -- where people were living and where migration was happening -- but what we didn't know was how that changed social networks," Mills said. "We're so used to looking traditionally at distributions of pottery and other objects based on their occurrence in space, but to see how social relationships are created out of these distributions is what network analysis can help with."
One of Mills's collaborators on the project was Ronald Breiger, renowned network analysis expert and a UA professor of sociology, with affiliations in statistics and government and public policy, who says being able to apply network analysis to archaeology has important implications for his field.
"Barbara (Mills) and her group are pioneers in bringing the social network perspective to archaeology and into ancient societies," said Breiger, who worked with Mills along with collaborators from the UA School of Anthropology; Archaeology Southwest; the University of Wisconsin, Milwaukee; Hendrix College; the University of Colorado, Boulder; the Santa Fe Institute; and Archaeological XRF Laboratory in Albuquerque, N.M.
"What archaeology has to offer for a study of networks is a focus on very long-term dynamics and applications to societies that aren't necessarily Western, so that's broadening to the community of social network researchers," Breiger said. "The coming together of social network and spatial analysis and the use of material objects to talk about culture is very much at the forefront of where I see the field of social network analysis moving."
Going forward, Mills hopes to use the same types of analyses to study even older social networks.
"We have a basis for building on, and we're hoping to get even greater time depth. We'd like to extend it back in time 400 years earlier," she said. "The implications are we can see things at a spatial scale that we've never been able to look at before in a systematic way. It changes our picture of the Southwest."
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The above story is reprinted from materials provided by University of Arizona. The original article was written by Alexis Blue.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Barbara J. Mills, Jeffery J. Clark, Matthew A. Peeples, W. R. Haas, Jr., John M. Roberts, Jr., J. Brett Hill, Deborah L. Huntley, Lewis Borck, Ronald L. Breiger, Aaron Clauset, and M. Steven Shackley. Transformation of social networks in the late pre-Hispanic US Southwest. PNAS, 2013 DOI: 10.1073/pnas.1219966110
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
At the World Series of Fighting's second show on Saturday, one-time UFC welterweight won over one-time UFC heavyweight champ Andrei Arlovski. As seen in the highlights above, Johnson had Arlovski hobbled at the end of the first round, but Arlovski was saved by the bell. Arlovski's jaw was reportedly broken in the bout that was Johnson's first fight at heavyweight.
As a welterweight who was bigger than other 170 lbers in the UFC, he struggled with his weight cut and missed weight three times. He moved to light heavyweight last August, and now won his heavyweight debut.
In other WSOF action, Marlon Moraes won his fourth straight by knocking out Tyson Nam with a headkick. Paulo Filho, the troubled one-time WEC champ, dropped a decision to Dave Branch.
Josh Burkman knocked out Aaron Simpson in the first round. After the fight, he said the win earned him a title shot, but questioned if one-time UFC title contender Jon Fitch had earned the WSOF title shot against him.
COLUMBUS, Ohio (AP) -- Ohio drivers are seeing another slight bump at the gas pump to start the work week.
A gallon of regular gas in Ohio was listed at an average of $3.70 in Monday's survey from auto club AAA, the Oil Price Information Service and Wright Express. That's 3 cents more than last Monday's average of $3.67.
The national average for regular gas is about $3.67 per gallon, down about 2 cents from a week ago.
The lowest average price in Ohio was about $3.64 in the Youngstown and Warren areas in northeast Ohio.
Direct marketing means advertising techniques that make you get in direct contact with the customers. Direct mails, emails, online advertisement, text messaging and websites. And coming up with an effective mailing list that really works for your business requires some intelligent thinking. In short, you should be well aware of the market you are targeting; then reaching them through effective direct marketing techniques will ensure an ongoing success for your business.
The first step in the process is to identify sources that can provide you with useful customer information. The information can be taken from internal and external sources, the former being held by the company within itself while for latter, you will have to do some searching. The external sources include various directories, websites, internet sources that provide such information, and surveys and reports.
For creating an effective list, you can partition your list according to your customer?s buying pattern, lifestyle or wealth. Revisit your list and keep updating where necessary. There is always new data that needs to be focused on; new customers, checking on responses from existing customers, and identifying new prospects through internet searches. If you cannot create your own list, you can always make use of the existing ones. You can either use these or ask for a custom made list, made to suit your business requirements better. Just remember one thing: your list needs to be used immediately as changes keep happening all the time that can alter the data on your list altogether. Lists can be bought or rented; a one time campaign is more than enough with one list, so renting could work for you. Before buying a list, do check if it falls wiyhin the profile you want. Taking care of a few minor things like those mentioned above, you can get a perfect mailing list to successfully market your business.
Mar. 22, 2013 ? In August 2011, researchers from the U.S. Department of Agriculture were presented with a serious, and potentially very costly, puzzle in Kennewick, Wash. Since Kennewick lies within a region near the heart of Washington state's $1.5 billion apple-growing region, an annual survey of fruit trees is performed by the Washington State Department of Agriculture (WSDA) to look for any invading insects. This time the surveyors discovered a crabapple tree that had been infested by a fruit fly that they couldn't identify.
It was possible that the fly's larvae, eating away inside the crabapples as they grew toward adulthood, belonged to a relatively harmless species that had simply expanded its traditional diet. In that case, they posed little threat to the surrounding apple orchards in central Washington.
But the real fear was that they represented an expansion in the range of the invasive apple maggot fly, known to biologists as Rhagoletis pomonella. If so, then this would trigger a costly quarantine process affecting three counties in the state.
"In one of the world's leading apple-growing regions, a great deal of produce and economic livelihood rested on quickly and accurately figuring out which one of the flies was in that tree," says Jeffrey Feder, professor of biological sciences and a member of the Advanced Diagnostics & Therapeutics initiative (AD&T) at the University of Notre Dame. "And for these flies, it can sometime turn out to be a difficult thing to do."
As Feder and his team, including graduate student Gilbert St. Jean and AD&T research assistant professor Scott Egan, discuss in a new study in the Journal of Economic Entomology, the WSDA sent larvae samples to Wee Yee, research entomologist at the USDA's Yakima Agricultural Research Laboratory in Wapato, Wash. One larva was sent to Notre Dame for genetic analysis. The study sought to compare Notre Dame's genetic analysis to Yee's visual identification after the larvae had developed into adults. Fortunately, the fly identified, Rhagoletis indifferens, is not known to infest apples. The Notre Dame group further demonstrated that it is possible to genetically identify the correct fly species within two days, compared to the four months required to raise and visually identify the fly.
A separate study led by the Feder lab details how the apple maggot fly was recently introduced into the Pacific Northwest region of the U.S., likely via larval-infested apples from the East. The flies have subsequently reached as far north as British Columbia, Canada, and as far south as northern California. So far, though, the apple maggot has not been reported infesting any commercial apple orchards in central Washington.
"The correct identification of the larvae infesting crabapple trees saved the local, state and federal agencies thousands of dollars in monitoring, inspection and control costs," Yee said. "The cost to growers if the apple maggot had been found to be established in the region would have been very substantial (easily over half a million dollars), but the rapid diagnostic test developed at Notre Dame suspended the need to proceed with the rulemaking process, saving staff and administrative costs."
The Feder team is continuing to refine the genetic assays to develop a portable test that would be valuable in apple-growing regions, as well as ports of entry where fruit infested by nonlocal insect species can be rapidly detected, to prevent the spread of the insect.
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The above story is reprinted from materials provided by University of Notre Dame. The original article was written by Kirk Reinbold.
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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
Hip implant patients with unexplained pain likely to have tissue damagePublic release date: 20-Mar-2013 [ | E-mail | Share ]
Contact: Phyllis Fisher phyllis.fisher@gmail.com 212-606-1724 Hospital for Special Surgery
The cause of unexplained pain among metal-on-metal hip implant patients is more likely to be tissue damage than wear of the implant, Hospital for Special Surgery researchers have found. The study, performed by Dr. Danyal Nawabi, orthopedic surgery fellow, and research collaborators at HSS, will be reported at the upcoming annual meeting of the American Academy of Orthopaedic Surgeons, March 19-23, in Chicago.
Researchers set out to determine causes of unexplained pain among patients with metal-on-metal hip implants (in which the ball and socket are both made of metal) who came to the hospital for revision surgery. Metal-on-metal implants have potential advantages, said Timothy Wright, Ph.D., Kirby Chair of Orthopedic Biomechanics at Hospital for Special Surgery (HSS): "If they remain well lubricated, as happens with the oil in your car, it minimizes wear." In addition, surgeons can implant a bigger head, or ball, making the hip joint more stable. But nationwide, failure of metal-on-metal hip devices due to unexplained pain is rising.
The research group, which did not have any ties to hip implant manufacturers, was led by Dr. Douglas Padgett, chief of the Adult Reconstruction and Joint Replacement Division and chief of the Hip Service at HSS, and Dr. Hollis Potter, chief of the Division of Magnetic Resonance imaging (MRI). They compared 50 patients (33 with total hip arthroplasties and 17 with hip resurfacing arthroplasties) who came to HSS for revision surgery because of unexplained pain, to a control group of 48 patients (23 with total hip arthroplasties and 25 with hip resurfacing arthroplasties) who came to HSS for revision surgery because of loosening, malalignment, infection or fracture. The investigators combined results from clinical examinations of the patients, magnetic resonance imaging, wear analysis studies on the removed implants, and pathology studies of tissues removed at surgery, including the degree of aseptic lymphocytic vasculitis-associated lesions (ALVAL), a sign of adverse tissue reactions to metal debris.
Thirty patients with unexplained pain (60% of the group) had an ALVAL score of at least 5 on a 10-point scale, indicating moderate to high adverse tissue reactions. Twelve percent of patients had some buildup of metal deposits in their soft tissue. The average synovial thickness was three times higher in the unexplained pain group compared to the control group, and the average synovial fluid volume was five times higher in the unexplained pain group compared to the control group. Ten times as many patients in the unexplained pain group had high-grade tissue damage scores compared to the control group.
Researchers found no differences between the unexplained pain group and the control group in terms of age, sex, body mass index, length of implantation, or size or positioning of the implants. Implants in both groups showed similar signs of wear.
"We found that some patients had a significant amount of tissue damage but not a lot of wear," Dr. Wright said, "suggesting that factors other than wear are contributing to the problem regardless of whether the patients have pain. We have used the information from our study to develop guidelines for patients and surgeons."
"Hip implant patients with unexplained pain should be followed closely by their surgeon,"
added Dr. Padgett. "Early identification of patients with unexplained pain is vital to avoid significant tissue damage. The work by Dr. Potter using novel MRI protocols has proven to be invaluable in diagnosing and monitoring these patients."
HSS doctors perform more than 9,000 joint replacement surgeries per year, of which about 10 percent are revision surgeries. Many patients who have had their joint replacement surgeries elsewhere come to HSS for revision surgery.
###
Other Hospital for Special Surgery investigators involved in the study include Nader A. Nassif, M.D.; Stephanie L. Gold; Kirsten Stoner, M.S.; Marcella Elpers; and Edwin P. Su, M.D.
Unexplained Pain in Failed Metal-on-Metal Hip Arthroplasty: A Retrieval, Histological and Imaging Analysis (Paper 70)
Wednesday, March 20, 9:12 a.m. CDT, McCormick Place, Room N427
About Hospital for Special Surgery
Founded in 1863, Hospital for Special Surgery (HSS) is a world leader in orthopedics, rheumatology and rehabilitation. HSS is nationally ranked No. 1 in orthopedics, No. 3 in rheumatology, No. 10 in neurology and No. 5 in geriatrics by U.S. News & World Report (2012-13), and is the first hospital in New York State to receive Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center three consecutive times. HSS has one of the lowest infection rates in the country. From 2007 to 2011, HSS has been a recipient of the HealthGrades Joint Replacement Excellence Award. HSS is a member of the NewYork-Presbyterian Healthcare System and an affiliate of Weill Cornell Medical College and as such all Hospital for Special Surgery medical staff are faculty of Weill Cornell. The hospital's research division is internationally recognized as a leader in the investigation of musculoskeletal and autoimmune diseases. Hospital for Special Surgery is located in New York City and online at http://www.hss.edu.
For more information contact:
Phyllis Fisher
212-606-1197
FisherP@hss.edu
phyllis.fisher@gmail.com
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Hip implant patients with unexplained pain likely to have tissue damagePublic release date: 20-Mar-2013 [ | E-mail | Share ]
Contact: Phyllis Fisher phyllis.fisher@gmail.com 212-606-1724 Hospital for Special Surgery
The cause of unexplained pain among metal-on-metal hip implant patients is more likely to be tissue damage than wear of the implant, Hospital for Special Surgery researchers have found. The study, performed by Dr. Danyal Nawabi, orthopedic surgery fellow, and research collaborators at HSS, will be reported at the upcoming annual meeting of the American Academy of Orthopaedic Surgeons, March 19-23, in Chicago.
Researchers set out to determine causes of unexplained pain among patients with metal-on-metal hip implants (in which the ball and socket are both made of metal) who came to the hospital for revision surgery. Metal-on-metal implants have potential advantages, said Timothy Wright, Ph.D., Kirby Chair of Orthopedic Biomechanics at Hospital for Special Surgery (HSS): "If they remain well lubricated, as happens with the oil in your car, it minimizes wear." In addition, surgeons can implant a bigger head, or ball, making the hip joint more stable. But nationwide, failure of metal-on-metal hip devices due to unexplained pain is rising.
The research group, which did not have any ties to hip implant manufacturers, was led by Dr. Douglas Padgett, chief of the Adult Reconstruction and Joint Replacement Division and chief of the Hip Service at HSS, and Dr. Hollis Potter, chief of the Division of Magnetic Resonance imaging (MRI). They compared 50 patients (33 with total hip arthroplasties and 17 with hip resurfacing arthroplasties) who came to HSS for revision surgery because of unexplained pain, to a control group of 48 patients (23 with total hip arthroplasties and 25 with hip resurfacing arthroplasties) who came to HSS for revision surgery because of loosening, malalignment, infection or fracture. The investigators combined results from clinical examinations of the patients, magnetic resonance imaging, wear analysis studies on the removed implants, and pathology studies of tissues removed at surgery, including the degree of aseptic lymphocytic vasculitis-associated lesions (ALVAL), a sign of adverse tissue reactions to metal debris.
Thirty patients with unexplained pain (60% of the group) had an ALVAL score of at least 5 on a 10-point scale, indicating moderate to high adverse tissue reactions. Twelve percent of patients had some buildup of metal deposits in their soft tissue. The average synovial thickness was three times higher in the unexplained pain group compared to the control group, and the average synovial fluid volume was five times higher in the unexplained pain group compared to the control group. Ten times as many patients in the unexplained pain group had high-grade tissue damage scores compared to the control group.
Researchers found no differences between the unexplained pain group and the control group in terms of age, sex, body mass index, length of implantation, or size or positioning of the implants. Implants in both groups showed similar signs of wear.
"We found that some patients had a significant amount of tissue damage but not a lot of wear," Dr. Wright said, "suggesting that factors other than wear are contributing to the problem regardless of whether the patients have pain. We have used the information from our study to develop guidelines for patients and surgeons."
"Hip implant patients with unexplained pain should be followed closely by their surgeon,"
added Dr. Padgett. "Early identification of patients with unexplained pain is vital to avoid significant tissue damage. The work by Dr. Potter using novel MRI protocols has proven to be invaluable in diagnosing and monitoring these patients."
HSS doctors perform more than 9,000 joint replacement surgeries per year, of which about 10 percent are revision surgeries. Many patients who have had their joint replacement surgeries elsewhere come to HSS for revision surgery.
###
Other Hospital for Special Surgery investigators involved in the study include Nader A. Nassif, M.D.; Stephanie L. Gold; Kirsten Stoner, M.S.; Marcella Elpers; and Edwin P. Su, M.D.
Unexplained Pain in Failed Metal-on-Metal Hip Arthroplasty: A Retrieval, Histological and Imaging Analysis (Paper 70)
Wednesday, March 20, 9:12 a.m. CDT, McCormick Place, Room N427
About Hospital for Special Surgery
Founded in 1863, Hospital for Special Surgery (HSS) is a world leader in orthopedics, rheumatology and rehabilitation. HSS is nationally ranked No. 1 in orthopedics, No. 3 in rheumatology, No. 10 in neurology and No. 5 in geriatrics by U.S. News & World Report (2012-13), and is the first hospital in New York State to receive Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center three consecutive times. HSS has one of the lowest infection rates in the country. From 2007 to 2011, HSS has been a recipient of the HealthGrades Joint Replacement Excellence Award. HSS is a member of the NewYork-Presbyterian Healthcare System and an affiliate of Weill Cornell Medical College and as such all Hospital for Special Surgery medical staff are faculty of Weill Cornell. The hospital's research division is internationally recognized as a leader in the investigation of musculoskeletal and autoimmune diseases. Hospital for Special Surgery is located in New York City and online at http://www.hss.edu.
For more information contact:
Phyllis Fisher
212-606-1197
FisherP@hss.edu
phyllis.fisher@gmail.com
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Marco Rubio came in a close second to Rand Paul in CPAC's presidential straw poll. But Florida's junior senator has a lot going for him as he?has morphed into a mainstream Republican favorite.
By Linda Feldmann,?Staff writer / March 17, 2013
Senator Marco Rubio of Florida speaks at the Conservative Political Action Conference (CPAC) at National Harbor, Maryland March 14. Rubio?s speech got the packed ballroom to its feet with an approach that was more inspirational than hard-edged.
Kevin Lamarque/REUTERS
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Marco Rubio, the junior senator from Florida, came in second Saturday to Kentucky Sen. Rand Paul in the presidential straw poll at the big annual Conservative Political Action Conference, or CPAC.
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But just barely. Senator Rubio got 23 percent to Senator Paul?s 25 ? the only two people to score in double digits of the 23 potential candidates on the ballot (plus 44 write-ins).
There are two big reasons to discount the poll: It?s unscientific and the 2016 presidential election is far away.
Some attendees didn?t bother to vote, they said, because they?re more focused on the 2014 midterms. And more than half (52 percent) of the 2,390 people who did vote were between the ages of 18 and 25 ? hardly typical of the Republican electorate, though reflective of CPAC?s success in attracting young people. Many of today?s college Republicans lean libertarian like Paul.
Still, Rubio can take heart from his performance in the first cattle call of the 2016 cycle. Though elected to the Senate in 2010 as a tea party darling (like Paul), he has morphed into a mainstream GOP favorite. Rubio?s CPAC speech wasn?t as pungent as Paul?s ? ?The GOP of old has grown stale and moss-covered,? the Kentuckyian said ? but he still got the packed ballroom to its feet Thursday with an approach that was more inspirational than hard-edged.
?We don't need a new idea,? Rubio said. ?There is an idea. The idea is called America, and it still works.?
Rubio also tossed in some red meat to social conservatives, defending traditional marriage, opposition to abortion, and skepticism on climate change. But he didn?t dwell on those topics, and on gay marriage, he occupied a middle ground, allowing that states have the right to define marriage how they wish.??
Rubio?s speech was mostly focused on the economy, and he sounded almost Obama-esque in his discussion of the middle class and education. He spoke of a family he knows that wants to reach the middle class, but with parents who lack the training for jobs that would get them there.
?They're not freeloaders. They're not liberals,? Rubio said, winning some laughs. ?They're just everyday people that want what everybody else wants?.They want a better life for themselves and an even better life for their children.?
Except for the slap at liberals, that could have been President Obama speaking. Rubio also played it safe on immigration, making no mention of the issue, his new support for a path to citizenship for illegal immigrants, or his role in the Senate trying to forge a bipartisan consensus.
Paul?s posture was more that of an outsider, attacking Obama and the Washington establishment (of both parties), highlighting his recent 13-hour filibuster over drones, and issuing populist appeals to the young and libertarian-minded.
?Ask the Facebook generation whether we should put a kid in jail for the nonviolent crime of drug use, and you'll hear a resounding no,? Paul said. ?Ask the Facebook generation if they want to bail out too-big-to-fail banks with their tax dollars, and you'll hear a ?Hell no.??
He also tried to outdo House Budget Chairman Paul Ryan of Wisconsin, calling for a budget that reaches balance in five years. (Congressman Ryan?s budget gets there in 10). And he called for elimination of the Department of Education, echoing President Reagan from 30 years ago.
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The genome of the cell line, which originated from a deadly cervical tumor taken from a patient named Henrietta Lacks, is riddled with errors, raising questions about its continued use in research
By Ewen Callaway and Nature magazine
HeLa cells have contributed to work in thousands of research papers but sequencing shows their genome to be full of errors.Image: Flickr/GE Healthcare
The research world?s most famous human cell has had its genome decoded, and it?s a mess. German researchers this week report the genome sequence of the HeLa cell line, which originates from a deadly cervical tumor taken from a patient named Henrietta Lacks.
Established after Lacks died in 1951, HeLa cells were the first human cells to grow well in the laboratory. The cells have contributed to more than 60,000 research papers, the development of a polio vaccine in the 1950s and, most recently, an international effort to characterize the genome, known as ENCODE.
Previous work showed that HeLa cells, like many tumors, have bizarre, error-filled genomes, with one or more extra copies of many chromosomes. To get a closer look at these alterations, a team led by Lars Steinmetz, a geneticist at the European Molecular Biology Laboratory in Heidelberg, Germany, sequenced the popular 'Kyoto' version of the cell line and compared the sequence with that of a reference human genome. The team's results are published in G3.
Steinmetz?s team confirmed that HeLa cells contain one extra version of most chromosomes, with up to five copies of some. Many genes were duplicated even more extensively, with four, five or six copies sometimes present, instead of the usual two.? Furthermore, large segments of chromosome 11 and several other chromosomes were reshuffled like a deck of cards, drastically altering the arrangement of the genes.
Without the genome sequence of Lacks? healthy cells or that of her original tumor, it is difficult to trace the origin of these alterations. Steinmetz points out that other cervical tumors have massive rearrangements on chromosome 11, so the changes in the HeLa cell may have contributed to Lacks? tumor.
Potential uses Having been replicating in labs around the world for six decades, HeLa cells have also accrued errors not present in the original tumor DNA. Moreover, not all HeLa cells are identical, and Steinmetz says that it would be interesting to chart the cell?s evolution.
Whatever their origin, the genetic changes raise questions over the widespread use of HeLa cells as models for human cell biology, Steinmetz says. For instance, his team found that around 2000 genes are expressed at levels higher than those of normal human tissues because of the duplications. Alternative cell lines, such as induced pluripotent stem cells generated from patient skin cells, offer a more accurate window on human biology, he says.
Mathew Garnett, a cancer biologist at the Wellcome Trust Sanger Institute near Cambridge, UK, says that HeLa cells could prove useful for studying aspects of the biology of cervical tumors, such as their response to cancer drugs. In recent years, the genomes of many cervical tumors have been sequenced, and so it should be possible to see how these compare with the HeLa genome.
Steinmetz also points out that thousands of research papers based on HeLa cells, along with HeLa resources such as genetically manipulated lines and now a genome, means that labs will continue to stock the cells, even if they are not a perfect model of human biology. ?These are not going to go out of fashion over the next 10 years,? he says. "I?m not sure where we?re going to be 20 years from now."
This article is reproduced with permission from the magazine Nature. The article was first published on March 15, 2013.
NEW YORK (Reuters) - A federal judge has ruled unconstitutional national security provisions that permit federal investigators to access customer information from some companies without court approval.
The provisions "suffer from significant constitutional infirmities," and violate the First Amendment and separation of powers, Judge Susan Illston of the District Court for the Northern District of California wrote in an order on Thursday.
The judge's decision stems from a "National Security Letter" that the Federal Bureau of Investigation issued to an unnamed telecommunications company, according to the Electronic Frontier Foundation.
The National Security Letter provision of the Patriot Act expanded the FBI's authority to demand personal customer records from Internet service providers, financial institutions and credit companies without prior court approval, according to the American Civil Liberties Union.
The letter to the telecommunications company sought "subscriber information" from the company, and warned that the letter's disclosure could result "in a danger to the United States," among other ramifications, according to the decision.
In the lawsuit, the company challenged the constitutionality of the laws, while the government opposed it and filed its own lawsuit, according to the decision.
"The government has a strong argument that allowing the government to prohibit recipients of NSL's from disclosing the specific information sought in NSL's to either the targets or the public is generally necessary to serve national security in ongoing investigations," Illston wrote. "However, the government has not shown that it is generally necessary to prohibit recipients from disclosing the mere fact of their receipt of NSLs."
Ever wonder what goes through Vice President Joe Biden's head? The White House has just launched an audio series called "Being Biden," where the vice president will share his story of a photograph in which he appears.
The first picture featured in the series is of Biden's serving rolls at a wild game dinner in Delaware earlier this month. The vice president is shaking hands with a man wearing a hunting-style shirt featuring deer in the woods as Biden carries a tong in his other hand.
"Hey folks, I want to tell you about this picture you're looking at," Biden said about the picture. "These are a couple of guys in their hunting shirts that I'm serving a meal to, along with the folks you see in the back gourd and the occasion is once a year the Whitehall Neck Sportsman Club holds a dinner.
"I've been attending it for over 30 years. It's called a wild game dinner and they go out and they hunt for wild game that they then cook up and serve at the Leipsic fire hall, as you see in the background and all the money goes to charity and then there's an auction and they auction off guns and bows and all that money as well goes to originally went to [defray] the costs and expenses of a buddy of theirs who was injured in a hunting accident years ago and now it goes to help people in need."
Biden then detailed how important the right to bear arms responsibly is to himself and hunters.
"They believe there is a Second Amendment right to own a weapon. So do I, but they also believe that it's for self protection and legitimate uses like hunting and these guys have the ethic, an ethic that I find most sportsmen have, one that demands responsibility in terms of their case how you deal with, treat, and store your weapons, and there's an ethic that they have that says we're going to help those in our community who are in need," Biden said. "I know these guys, and I know an awful lot of them. I've been doing it for over 30 years. They're my friends, but the point is they are absolutely, totally responsible."
The vice president noted that today marks three months since the massacre at Sandy Hook Elementary in Connecticut and urged Congress to pass gun legislation to help prevent such a tragedy in the future.
"This is the third-month anniversary of those twenty beautiful little babies who were massacred up in Connecticut in Sandy Hook and those six brave teachers and administrators that tried to protect them. And the country cries for responsible action, to do everything we can to see to it that these kinds of events don't happen again," he said.
"I'm pleased to say the Judiciary Committee, that's the committee in the United States Senate has passed out the major elements of what we've proposed. They've passed out a gun-trafficking piece of legislation, a universal background check piece, a school safety piece, and I think they're going to do more," Biden said.
"I think it's time the United States Congress act responsibly now and seriously debate the pieces of legislation we've talked about so that we can get to a position where we actually make our communities safer for our children, make our schools safer, and make society safer."
Melbourne IT (ASX: MLB) today announced it had entered into definitive agreements with respect to the sale of its Digital Brand Services (DBS) division to US-based Corporation Services Company (CSC) for a cash consideration of A$152.5 ($157.2 USD) million. The completion of the transaction occurred simultaneously with execution of these agreements.
Key Points:
A$152.5 million cash received by Melbourne IT for Digital Brand Services (DBS) division
Board considering capital management options including special dividends, capital returns, share buybacks and business investment options for use of DBS sale proceeds
Melbourne IT strongly positioned for future growth with systems transformation project in its final year
Management and Board to deliver updated Melbourne IT strategic business plan to shareholders by AGM in May
DBS provides online brand protection and consultancy services to large global organisations seeking to maximise the value of their online assets. The division was created in 2008 when Melbourne IT combined its Corporate Brand Services division with the Verisign DBMS business which the company had acquired for US$50 million.
The agreed sale price of A$152.5 million for DBS illustrates a significant growth in value of the business over the past four years, and represents a valuation of 16x 2012 segment EBIT (pre-corporate allocations) of $9.5 million and is equivalent to 95% of Melbourne IT?s market capitalisation pre-DBS sale (as of 11 March 2013). The sale achieves the Melbourne IT Board?s stated objective of its strategic review to unlock shareholder value by realising the intrinsic value of its businesses.
Melbourne IT Chairman, Simon Jones, said: ?The Board firmly believes this transaction is in the interests of shareholders.?
Ten per cent of the A$152.5 million purchase price will be held in escrow for 15 months. Net proceeds from the transaction will depend on Melbourne IT?s capital gains tax liability, transaction and other associated costs, and other sale related adjustments, however are expected to be in the order of A$135-140 million. After retiring outstanding debt of US$35 million, Melbourne IT will consider a range of capital management options as a result of the sale.
?The sale of DBS is a substantial result for shareholders. The transaction has crystallised a value for the business almost equivalent to Melbourne IT?s current market capitalisation, and represents a strong multiple of earnings relative to other recent transactions for this type of business. While this was not a business that we had specifically earmarked for sale, given the value creation provided by the transaction, this was an opportunity which could not be ignored,? Melbourne IT CEO and Managing Director, Theo Hnarakis, said.
?Management and the Board are now concentrating on updating the strategic plan for the business following the divestiture so we can provide clarity to shareholders before the AGM in May. We are confident that Melbourne IT?s remaining business divisions will benefit significantly from the arrival of new gTLDs, the completion of the Transformation program, and management?s clearer focus on executing our plans,? he said.
Corporation Service Company (CSC) Vice President, Jim Stoltzfus, said of the sale: ?We were attracted to the global scale and capabilities of DBS to combine with CSC?s leadership position in providing corporate domain and online services to create the best partner for companies worldwide to turn to for helping them manage, promote and protect their brands in the digital marketplace.?
The proceeds of the DBS sale will be realised in Melbourne IT?s 2013 financial year which began January 1, 2013. In the interest of shareholders, Melbourne IT has decided to suspend the Dividend Reinvestment Plan while the strategic review completes.
Melbourne IT is being advised on the transaction by King & Wood Mallesons and Lazard. ENDS.
About Melbourne IT Melbourne IT (ASX: MLB) helps organizations of all sizes to successfully conduct business online. Our complete portfolio of Internet-based technology services drives business effectiveness and profitability for more than 400,000 customers around the world.
The breadth of Melbourne IT?s offering extends from helping small businesses build an online presence through to managing the complex technology environments of large enterprises and governments ? including Internet domain name services, web hosting, online brand protection and promotion, managed IT services and more.
Melbourne IT?s culture of integrity, innovation, collaboration and customer centricity has been built by more than 650 employees spread across 18 offices in 10 countries. For more information, visit www.melbourneit.info.
About Corporation Service Company Founded in 1899, Corporation Service Company (CSC) provides business, legal, and financial services to many of the world?s largest companies, law firms, and financial institutions.
An ICANN-accredited domain name registrar since 1999, CSC is the trusted partner of more than half the 100 Best Global Brands (Interbrand?) and the customer approval leader for domain name and online services (World Trademark Review, 2010). CSC offers an end-to-end solution for every corporate brand protection need, from strategic domain registration and online monitoring to digital certificates and trademark screening.
CSC has more than 1,600 employees located throughout North America and Europe. Visit www.cscglobal.com to learn more.
About the Author:
Konstantinos Zournas lives in Athens, Greece. He studied Computer Engineering and Computer Science in the UK. He has been a domainer, among other things, for the past 10 years. He does consulting, website development and programming. He is mainly writing about domain names but other things may come up. You can find him at Google+
Konstantinos Zournas ? who has written 454 posts on Online Domain.
Mar. 12, 2013 ? Among adults without diabetes, quitting smoking, compared with continuing smoking, was associated with a lower risk of cardiovascular disease despite subsequent weight gain, according to a study appearing in the March 13 issue of JAMA.
"Cigarette smoking is the leading cause of preventable mortality in the United States and a major risk factor for cardiovascular disease (CVD). Smoking cessation substantially reduces the risks of CVD; however, quitting smoking is associated with a small number of adverse health consequences, weight gain being one of smokers' major concerns," according to background information in the article. The average postcessation weight gain varies between 6.6 lbs. and 13.2 lbs. in North America, happens within 6 months after smoking cessation, and persists over time. Obesity is also a risk factor for CVD. Weight gain following smoking cessation therefore might lessen the benefits of quitting smoking on CVD outcomes. In addition, among people with type 2 diabetes, weight gain following smoking cessation has potential to be of greater concern because it is a risk factor for poor diabetes control and increased risk of illness and death. "The effect on CVD of potential weight gain following smoking cessation is not well understood," the authors write.
Carole Clair, M.D., M.Sc., of the University of Lausanne, Switzerland, and colleagues conducted a study to assess the association between 4-year weight gain following smoking cessation and CVD event rate among adults with and without diabetes. The study included data from the Framingham Offspring Study collected from 1984 through 2011. At each 4-year examination, self-reported smoking status was assessed and categorized as smoker, recent quitter (? 4 years), long-term quitter (>4 years), and nonsmoker. Models were used to estimate the association between quitting smoking and 6-year CVD events and to test whether 4-year change in weight following smoking cessation modified the association between smoking cessation and CVD events. The primary outcome measure was the incidence over 6 years of total CVD events, comprising coronary heart disease, cerebrovascular events, peripheral artery disease, and congestive heart failure.
Weight gain occurred over 4 years in participants without and with diabetes. Among participants without diabetes, recent quitters gained significantly more weight (median [midpoint], 5.9 lbs.) than long-term quitters (1.9 lbs.), smokers (1.9 lbs.), and nonsmokers (3 lbs.). Among patients with diabetes, recent quitters also gained significantly more weight (7.9 lbs.) than smokers (1.9 lbs.), long-term quitters (0.0 lbs., and nonsmokers (1.1 lbs.).
After an average follow-up of 25 years, 631 CVD events occurred among 3,251 participants. The researchers found that among participants without diabetes, the age- and sex-adjusted CVD incidence rates were lower for nonsmokers, recent quitters, and long-term quitters, compared with smokers.
After adjustment for CVD risk factors, compared with smokers, recent quitters had a 53 percent lower risk for CVD and long-term quitters had a 54 percent lower risk for CVD; these associations had only a minimal change after further adjustment for weight change. "Among participants with diabetes, there were similar point estimates that did not reach statistical significance," the authors write.
The researchers observed similar benefits associated with smoking cessation for total CVD and for fatal and non-fatal coronary heart disease, with the cessation benefits not offset by weight gain.
"In conclusion, among adults without diabetes, quitting smoking was associated with a lower risk of CVD compared with continuing smoking. There were qualitatively similar lower risks among participants with diabetes that did not reach statistical significance, possibly because of limited study power. Weight gain that occurred following smoking cessation was not associated with a reduction in the benefits of quitting smoking on CVD risk among adults without diabetes. This supports a net cardiovascular benefit of smoking cessation, despite subsequent weight gain," the authors write.
Editorial: Should Clinicians Encourage Smoking Cessation for Every Patient Who Smokes?
In an accompanying editorial, Michael C. Fiore, M.D., M.P.H., M.B.A., and Timothy B. Baker, Ph.D., of the University of Wisconsin School of Medicine and Public Health, Madison, suggest ways in which the findings of this study can be used by physicians.
"First, data from the study by Clair et al can be used to reassure patients concerned about the health effects of cessation-related weight gain. About 50 percent of female smokers and about 25 percent of male smokers are 'weight concerned,' which may discourage quit attempts and quitting success. Although such reassurance may not assuage concerns about the effects of weight gain on appearance, it may nevertheless be helpful. Furthermore, even though no treatments have been shown to reliably prevent cessation-related weight gain, exercise regimens may be beneficial, and use of nicotine replacement medications can suppress weight gain during their use. Second, physicians should use this information to reinforce their commitment to provide or arrange evidence based treatment for all of their patients who smoke."
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The above story is reprinted from materials provided by The JAMA Network Journals.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal References:
Clair C, Rigotti NA, Porneala B, et al. Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among Adults With and Without Diabetes. JAMA, 2013; 309 (10): 1014-1021 DOI: 10.1001/jama.2013.1644
Fiore MC, Baker TB. Should Clinicians Encourage Smoking Cessation for Every Patient Who Smokes?JAMA, 2013; 309 (10): 1032-1033 DOI: 10.1001/jama.2013.1793
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
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Public release date: 20-Mar-2013
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